Powdery-material feeding device and powdery-material feeding method

ABSTRACT

A powdery-material feeding device is configured to feed a powdery material to a compression-molding machine configured to obtain a molded product by filling a die bore with the powdery material and to compress the powdery material with punches. The powdery-material feeding device includes a detector configured to detect a biologically-originated foreign matter mixedly contained in the powdery material to be fed to the compression-molding machine, and a controller configured to control to remove the powdery material mixedly containing the biologically-originated foreign matter detected by the detector to avoid feeding of the powdery material mixedly containing the biologically-originated foreign matter to the compression-molding machine, or to control to stop the feeding of the powdery material to the compression-molding machine.

BACKGROUND

There has been known a rotary compression-molding machine including a table of a turret having die bores, an upper punch, and a lower punch slidably retained above and below each of the die bores, and configured to horizontally rotate the die bores and the punches together to compression mold a powdery material filled in the die bores when the paired upper and lower punches pass between an upper roll and a lower roll (see, for example, JP 2015-221458 A).

In a case where the compression-molding machine produces a molded product mixedly containing a metal piece, the metal piece can be sensed by checking the molded product with a metal detector. The molded product mixedly containing the metal piece can be distinguished and removed from normal molded products.

In another case where the powdery material fed to the compression-molding machine mixedly contains a biologically-originated foreign matter like a human hair or a bug, and molded products are produced from the powdery material, it is difficult to find a molded product containing such a biologically-originated foreign matter by checking completed molded products.

SUMMARY OF THE INVENTION

It is an exemplary object of the present invention to prevent the compression-molding machine from producing a molded product that mixedly contains a biologically-originated foreign matter.

The invention exemplarily provides a powdery-material feeding device configured to feed a powdery material to a compression-molding machine configured to obtain a molded product by filling a die bore with the powdery material and to compress the powdery material with punches. The powdery-material feeding device includes a detector configured to detect a biologically-originated foreign matter mixedly contained in the powdery material to be fed to the compression-molding machine, and a controller configured to control to remove the powdery material mixedly containing the biologically-originated foreign matter detected by the detector to avoid feeding of the powdery material mixedly containing the foreign matter to the compression-molding machine, or to control to stop the feeding of the powdery material to the compression-molding machine. This configuration prevents feeding, to the molding machine, of the powdery material mixedly containing the biologically-originated foreign matter.

The powdery-material feeding device is further configured to feed the compression-molding machine with mixed powdery materials containing at least two types of powdery materials. The powdery-material feeding device includes a detector configured to measure a mixing degree of the mixed powdery materials to be fed to the compression-molding machine. When the mixing degree of the mixed powdery materials detected by the detector is out of a predetermined range, the controller controls to remove the mixed powdery materials to avoid the feeding to the compression-molding machine or controls to stop the feeding of the mixed powdery materials to the compression-molding machine. This configuration prevents the feeding, to the molding machine, of the mixed powdery materials having a mixing degree out of a normal range as well as a biologically-originated foreign matter, to keep high quality of molded products.

When the powdery-material feeding device removes a powdery material mixedly containing foreign matter or powdery materials having an abnormal mixing degree, the powdery material fed from the powdery-material feeding device to the compression-molding machine can have a temporarily decreased flow rate per unit time. The compression-molding machine includes a rotary compression-molding machine and is configured to rotate a turret including a table having a die bore, and punch retaining portions vertically slidably retaining punches disposed above and below the die bore, along with the punches, and fill the die bore with a powdery material from a filling device disposed just above the table, to compress the powdery material filled in the die bore with the punches and to obtain a molded product. The controller controls to adjust a rotational speed of the turret and the punches of the rotary compression-molding machine to allow the powdery material in a feed pipe directly connected to the filling device and is further configured to feed the powdery material toward the filling device or in the filling device to have an upper surface level kept within a constant target range. This configuration achieves adjustment of an amount per unit time of a powdery material used by the molding machine in accordance with the flow rate of the powdery material fed from the powdery-material feeding device to the filling device.

Specifically, an increase in a rotational speed of the turret and the punches leads to an increase in an amount of the used powdery material per unit time, whereas a decrease in a rotational speed of the turret and the punches leads to a decrease in an amount of the used powdery material per unit time. An increase in an amount of the used powdery material per unit time leads to a decrease in an upper surface level of the powdery material in the feed pipe directly connected to the filling device or in the filling device, whereas a decrease in an amount of the used powdery material per unit time leads to an increase in an upper surface level of the powdery material in the feed pipe or in the filling device. When the upper surface level of the powdery material in the feed pipe or in the filling device is kept within a constant target range by adjustment of the rotational speed of the turret and the punches of the rotary compression-molding machine, the powdery material in the filling device constantly keeps pressure, and the filling device can keep filling the die bores with a constant amount of the powdery material. This leads to suppression of variation in weight, size, tableting pressure, and the like of the produced molded products.

The exemplary invention provides a method of feeding a powdery material to a compression-molding machine configured to obtain a molded product by filling a die bore with the powdery material and to compress the powdery material with punches. The powdery-material feeding method includes detecting a biologically-originated foreign matter mixedly contained in the powdery material to be fed to the compression-molding machine, and controlling to remove the powdery material mixedly containing the biologically-originated foreign matter detected during the detection to avoid feeding of the powdery material mixedly containing the foreign matter to the compression-molding machine or controlling to stop the feeding of the powdery material to the compression-molding machine.

The powdery-material feeding method is applied to feed the compression-molding machine with mixed powdery materials containing at least two types of powdery materials. The method further includes detecting by measuring a mixing degree of the mixed powdery materials to be fed to the compression-molding machine, and controlling to remove the mixed powdery materials to avoid feeding to the compression-molding machine or controlling to stop the feeding of the mixed powdery materials to the compression-molding machine when the mixing degree of the mixed powdery materials measured during the detection is out of a predetermined range.

The powdery-material feeding method is applied to the rotary compression-molding machine configured to rotate a turret including a table having a die bore, and punch retaining portions vertically slidably retaining punches disposed above and below the die bore, along with the punches, and fill the die bore with a powdery material from a filling device disposed just above the table, to compress the powdery material filled in the die bore with the punches and to obtain a molded product. The powdery-material feeding method further includes controlling to adjust a rotational speed of the turret and the punches of the rotary compression-molding machine to allow the powdery material in a feed pipe directly connected to the filling device and configured to feed the powdery material toward the filling device or in the filling device to have an upper surface level being kept within a constant target range.

A powdery material is an aggregate of minute solids and conceptually includes an aggregate of particles such as so-called granules and an aggregate of powder smaller than such particles. Examples of the powdery material include a powdery material containing a principal agent, an excipient, a binder, a disintegrant, a stabilizer, and a preservative. The powdery material according to the exemplary invention also includes a mixture of two or more types of powdery materials, and a powdery material containing the principal agent mixed with a lubricant such as magnesium stearate.

The exemplary invention may prevent the compression-molding machine from producing a molded product that mixedly contains a biologically-originated foreign matter.

BRIEF DESCRIPTION OF THE DRAWINGS

The exemplary aspects of the invention will be better understood from the following detailed description of the exemplary embodiments of the invention with reference to the drawings:

FIG. 1 is a side sectional view of a rotary compression-molding machine according to an exemplary embodiment of the exemplary invention;

FIG. 2 is a plan view of a main part of the rotary compression-molding machine according to the exemplary embodiment;

FIG. 3 is a cylindrical view of the rotary compression-molding machine according to the exemplary embodiment;

FIG. 4 is a perspective view of a powdery material mixing and feeding device according to the exemplary embodiment;

FIG. 5 is a side view of the powdery material mixing and feeding device according to the exemplary embodiment;

FIG. 6 is a side sectional view of a vertical mixer included in the powdery material mixing and feeding device according to the exemplary embodiment;

FIG. 7 is an enlarged side sectional view of a main part of the vertical mixer according to the exemplary embodiment;

FIG. 8 is a side sectional view of another exemplary vertical mixer;

FIG. 9 is a perspective view of an agitation shaft and an agitating rotor (e.g., second mixing member) of a horizontal mixer included in the powdery material mixing and feeding device according to the exemplary embodiment;

FIG. 10 is a side view of a main part of the powdery material mixing and feeding device according to the exemplary embodiment;

FIG. 11 is a perspective view of the main part of the powdery material mixing and feeding device according to the exemplary embodiment;

FIG. 12 is a perspective view of a main part of a powdery material mixing degree measurement device according to the exemplary embodiment;

FIG. 13 is a plan view of the main part of the powdery material mixing degree measurement device according to the exemplary embodiment;

FIG. 14 is a perspective view of a case of the powdery material mixing degree measurement device according to the exemplary embodiment;

FIG. 15 is a perspective view of a drive body of the powdery material mixing degree measurement device according to the exemplary embodiment;

FIG. 16 is a block diagram of a control system in a rotary compression-molding machine system according to the exemplary embodiment;

FIG. 17 is a plan view of a main part including a mounting position of a rotary encoder in the rotary compression-molding machine according to the exemplary embodiment;

FIG. 18 is a configuration diagram of a roll and a load cell included in the rotary compression-molding machine according to the exemplary embodiment;

FIG. 19 is a sectional view of a feed pipe of the powdery material mixing and feeding device according to the exemplary embodiment; and

FIG. 20 is a timing chart indicating a pattern of control conducted by the control system in the rotary compression-molding machine system according to the exemplary embodiment.

DETAILED DESCRIPTION OF AN EXEMPLARY EMBODIMENT

An exemplary embodiment of the exemplary invention will now be described with reference to the drawings. Initially described is an overview of an entire rotary compression-molding machine (hereinafter, referred to as the “molding machine”) according to the exemplary embodiment. As shown exemplarily in FIG. 1, the molding machine includes a frame 1 accommodating an upright shaft 2 that functions as a rotary shaft, and a turret 3 that is attached to a connection portion 21 disposed at the top of the upright shaft 2. A worm wheel 7 is attached to the lower end of the upright shaft 2. The worm wheel 7 meshes with a worm gear 10. The worm gear 10 is fixed to a gear shaft 9 that is driven by a motor 8. Drive power outputted from the motor 8 is transmitted to the gear shaft 9 by way of a belt 11, so as to rotate the upright shaft 2 by way of the worm gear 10 and the worm wheel 7. Rotation of the upright shaft 2 causes rotation of the turret 3 and punches 5 and 6.

The turret 3 horizontally rotates about the upright shaft 2, and more specifically, spins. The turret 3 includes a table (e.g., die disc) 31, an upper punch retaining portion 32, and a lower punch retaining portion 33. As shown exemplarily in FIG. 2, the table 31 has a substantially circular disc shape, and has a plurality of die bores 4 that is disposed in an outer circumferential portion and is aligned in a direction of rotation at predetermined intervals. Each of the die bores 4 vertically penetrates the table 31. The table 31 can alternatively include a plurality of divided plates. Instead of the die bores 4 formed directly in the table 31, a die member including the die bores 4 can be attached to the table 31.

The upper and lower punches 5 and 6 are disposed above and below each of the die bores 4 and are individually vertically slidable along the die bores 4. The upper punch retaining portion 32 retains upper punch trunks 52 while the lower punch retaining portion 33 retains lower punch trunks 62. The upper punches 5 each have a tip 53 that enters and exits corresponding one of the die bores 4. The lower punches 6 each have a tip 63 that is kept inserted in corresponding one of the die bores 4. The upper and lower punches 5 and 6 horizontally rotate about the upright shaft 2 along with the turret 3, more specifically, revolve.

As shown exemplarily in FIG. 17, the gear shaft 9 has an end connected, by way of a reduction gear 24, with a rotary encoder 23 configured to detect a rotation angle and a rotational speed of the gear shaft 9 as well as (the table 31, the die bores 4, and the punches 5 and 6 of) the turret 3. The rotary encoder 23 outputs a pulse signal every time the gear shaft 9 rotates by a predetermined angle. Upon receipt of a train of the pulse signals, a controller C (shown exemplarily in FIG. 16) included in a compression-molding machine system according to the exemplary embodiment is configured to detect the rotation angle and the rotational speed of the turret 3 (i.e., find a current position of each of the die bores 4 on the table 31). The reduction gear 24 reduces the rotational speed of the gear shaft 9 to be adapted to an input speed of the rotary encoder 23 and transmits the reduced rotational speed to the rotary encoder 23.

A feeder X functioning as a filling device is provided to fill the die bores 4 of the turret 3 with a powdery material. The feeder X can be a gravity feeder configured to simply drop a powdery material into the die bores 4 or an agitated feeder configured to drop, into the die bores 4, a powdery material being agitated by rotating an incorporated agitating rotor. The exemplary embodiment assumes that the feeder X is the agitated feeder. The feeder X is positioned on the outer circumferential portion of the rotating table 31, particularly, just above a revolution orbit of the die bores 4. The powdery material is fed to the feeder X from a powdery-material feed pipe 191 (shown exemplarily in FIGS. 10 and 11) functioning as a discharger M6 of a powdery material mixing degree measurement device M to be described later. A buffer tank 19 is provided to feed a feeding unit M5 of the powdery material mixing degree measurement device M with the powdery material.

As shown exemplarily in FIG. 3, a preliminary compression upper roll 12, a preliminary compression lower roll 13, a substantial compression upper roll 14, and a substantial compression lower roll 15 are disposed on orbits of the upper and lower punches 5 and 6 that revolve about the upright shaft 2. The preliminary compression upper roll 12 and the preliminary compression lower roll 13, as well as the substantial compression upper roll 14 and the substantial compression lower roll 15, are respectively paired in the vertical direction so as to sandwich the upper and lower punches 5 and 6. The preliminary compression upper roll 12 and the substantial compression upper roll 14 each press a head 51 of each of the upper punches 5, and the preliminary compression lower roll 13 and the substantial compression lower roll 15 each press a head 61 of each of the lower punches 6. The preliminary compression upper roll 12 and the preliminary compression lower roll 13, as well as the substantial compression upper roll 14 and the substantial compression lower roll 15, bias the upper and lower punches 5 and 6 to come closer to each other, so that end surfaces of the tips 53 and 63 compress from above and below the powdery material filled in the die bores 4.

The upper and lower punches 5 and 6 have the heads 51 and 61 pressed by the rolls 12, 13, 14, and 15, and the trunks 52 and 62 smaller in diameter than the heads 51 and 61, respectively. The upper punch retaining portion 32 of the turret 3 vertically slidably retains the trunks 52 of the upper punches 5, whereas the lower punch retaining portion 33 vertically slidably retains the trunks 62 of the lower punches 6. The tips 53 and 63 of the trunks 52 and 62 are thinner than the remaining portions and are substantially equal in diameter to an inner diameter of the die bores 4 so as to be inserted to the die bores 4. The punches 5 and 6 revolve to cause the rolls 12, 13, 14, and 15 to come closer to the heads 51 and 61 of the punches 5 and 6. The rolls 12, 13, 14, and 15 come into contact with the heads 51 and 61 so as to step thereonto. The rolls 12, 13, 14, and 15 further press the upper punches 5 downward and press the lower punches 6 upward. While the rolls 12, 13, 14, and 15 are in contact with flat surfaces of the punches 5 and 6, the punches 5 and 6 keep applying required pressure to the powdery material in the die bores 4.

As shown exemplarily in FIG. 18, the upper rolls 12 and 14 of the molding machine each have a load cell 121 configured to detect pressure applied to compress the powdery material in the die bore 4 by the rolls 12, 13, 14, and 15 via the punches 5 and 6. The controller C, according to the exemplary embodiment receives signals transmitted from the load cells 121 disposed at the rolls 12, 13, 14, and 15 to find a magnitude of the pressure applied to compress the powdery material by the preliminary compression rolls 12 and 13 (e.g., a preliminary compression pressure) and a magnitude of the pressure applied to compress the powdery material by the substantial compression rolls 14 and 15 (e.g., substantial compression pressure). The signals outputted from the load cells 121 form a pulse signal train having a peak when each of the pairs of punches 5 and 6 compresses the powdery material in a corresponding one of the die bores 4 with a maximum pressure. The controller C thus counts the number of pulse trains to find the number of molded products produced by the molding machine per unit time.

A molded-product collector is disposed downstream, in the direction of rotation of the turret 3 and the punches 5 and 6, of the position where the substantial compression upper roll 14 and the substantial compression lower roll 15 apply pressure. This molded-product collector includes a guide member 17 configured to guide a molded product pushed out of each of the die bores 4. The guide member 17 extends to have a proximal end located at a molded-product collecting position 18 and a distal end located closer to the center of the table 31 than a rotation locus of the die bores 4. The molded product pushed out of each of the die bores 4 by the corresponding lower punch 6 comes into contact with the guide member 17 and moves toward the molded-product collecting position 18.

A molded-product production process conducted by the molding machine will be described roughly. As shown exemplarily in FIG. 3, the lower punch 6 initially descends and the feeder X fills, with a powdery material (e.g., mixed powdery materials), the die bore 4 into which the tip 63 of the lower punch 6 is inserted. The lower punch 6 subsequently ascends such that the die bore 4 is filled with a required amount of the powdery material (e.g., mixed powdery materials), and the powdery material overflowing the die bore 4 is leveled.

The upper punch 5 then descends, and the preliminary compression upper roll 12 and the preliminary compression lower roll 13 press the head 51 of the upper punch 5 and the head 61 of the lower punch 6, such that the tips 53 and 63 of the punches 5 and 6 preliminarily compress the powdery material in the die bore 4. The substantial compression upper roll 14 and the substantial compression lower roll 15 subsequently press the head 51 of the upper punch 5 and the head 61 of the lower punch 6, such that the tips 53 and 63 of the punches 5 and 6 substantially compress the powdery material in the die bore 4.

The lower punch 6 then ascends until the upper end surface of the tip 63 of the lower punch 6 substantially reaches the level of the upper end of the die bore 4 (i.e., the top surface of the table 31) and pushes a molded product out of the die bore 4 onto the surface of the turret 3. The molded product pushed out of the die bore 4 is brought into contact with the guide member 17 by rotation of the turret 3, and moves along the guide member 17 to the molded-product collecting position 18.

The molded-product collector of the molding machine according to the exemplary embodiment has a molded-product removal mechanism W configured to select a specific molded product such as a sampled product or a defective product from among molded products collected at the molded-product collecting position 18. Specifically, the guide member 17 is provided therein with an air passage 16 for a pressurized air flow, and the air passage 16 has a distal end functioning as an air spray nozzle 16 a opened outward in the radial direction of the turret 3. A flow passage 20 connects an air feed source (not shown) such as a pump configured to feed pressurized air and the air passage 16, and a control valve 22 is disposed on the flow passage 20 to open and close the flow passage 20. Examples of the control valve 22 can include an electromagnetic solenoid configured to open in accordance with a control signal transmitted from the controller C.

If the control valve 22 is opened when the specific molded product pushed out of the die bore 4 passes by the air spray nozzle 16 a before contacting the guide member 17, then the air spray nozzle 16 a sprays pressurized air fed from the air feed source through the flow passage 20 and the air passage 16 in the guide member 17. The sprayed air blows the specific molded product outward from the table 31. The blown molded product will not reach the molded-product collecting position 18 ahead of the guide member 17. As described above, the molded-product removal mechanism W in the molding machine according to the exemplary embodiment includes the passages 16 and 20 for air fed from the air feed source, the air spray nozzle 16 a, and the control valve 22.

The molded-product removal mechanism W is also configured to sample a tableted molded product.

Described below is a powdery-material feeding device Z configured to deliver a powdery material toward the feed pipe 191 directly connected to the feeder X of the molding machine. As shown exemplarily in FIGS. 4 and 5, the powdery-material feeding device Z according to the exemplary embodiment includes three measuring feeders Z1 (Z1 a, Z1 b, and Z1 c). The number of measuring feeders Z1 changes depending on the number of types of powdery materials to be mixed. The powdery-material feeding device Z can include two, or four or more measuring feeders Z1 with no particular limitation in the number thereof.

The first to third measuring feeders Z1 a to Z1 c according to the exemplary embodiment measure and feed different types of powdery materials. These measuring feeders Z1 a to Z1 c can alternatively measure and feed a single type of a powdery material. In the exemplary embodiment, the first measuring feeder Z1 a, the second measuring feeder Z1 b, and the third measuring feeder Z1 c measure and feed a principal agent, a powdery material of an excipient like lactose, or the like, and a lubricant, respectively.

As shown exemplarily in FIGS. 4 and 5, the powdery-material feeding device Z includes the first measuring feeder Z1 a, the second measuring feeder Z1 b, a vertical mixer Z3 (e.g., a first mixer), a first connecting pipe Z2 a connecting the measuring feeders Z1 (Z1 a and Z1 b) and the vertical mixer Z3, a horizontal mixer Z4 (e.g., a second mixer), a second connecting pipe Z2 b connecting the vertical mixer Z3 and the horizontal mixer Z4, a third connecting pipe Z2 c connecting the third measuring feeder Z1 c and the horizontal mixer Z4, and a fourth connecting pipe Z2 d connecting the horizontal mixer Z4 and the buffer tank 19. FIG. 4 is a perspective view showing a state where the powdery-material feeding device Z is attached to the molding machine. FIG. 5 is a side view of the powdery-material feeding device Z. The measuring feeders (e.g., Z1 a, Z1 b, and Z1 c) can be modified in terms of their disposition, shapes, and the like, and are not limited to the aspect shown exemplarily in FIGS. 4 and 5.

The first measuring feeder Z1 a and the second measuring feeder Z1 b measure the powdery materials, namely, the principal agent and the excipient or the like, respectively, and simultaneously feed the first connecting pipe Z2 a with the powdery materials. The third measuring feeder Z1 c measures the powdery material, namely, the lubricant, and simultaneously feeds the third connecting pipe Z2 c with the powdery material. These measuring feeders Z1 are configured in accordance with the known loss in weight system (e.g., a loss integrated value system), and each conduct feedback control of causing a gravimetric sensor to constantly measure weight of a powdery material discharged from the feeder Z1, comparing to find whether or not the weight transitions to achieve a set target discharge flow rate, and increasing or decreasing a discharge rate of the feeder Z1 to reduce a difference between. Measuring the powdery materials to be fed and simultaneously feeding the connecting pipes Z2 a and Z2 c with the powdery materials stabilizes contents of the principal agent and the like in a molded product.

As described earlier, the first connecting pipe Z2 a connects the first measuring feeder Z1 a and the second measuring feeder Z1 b to the vertical mixer Z3, to feed the vertical mixer Z3 with the principal agent discharged from the first measuring feeder Z1 a and the excipient or the like discharged from the second measuring feeder Z1 b. The second connecting pipe Z2 b connects the vertical mixer Z3 and the horizontal mixer Z4, to feed the horizontal mixer Z4 with the mixed powdery materials of the principal agent and the excipient discharged from the vertical mixer Z3. The third connecting pipe Z2 c connects the third measuring feeder Z1 c and the horizontal mixer Z4, to feed the horizontal mixer Z4 with the lubricant discharged from the third measuring feeder Z1 c. The fourth connecting pipe Z2 d connects the horizontal mixer Z4 and the buffer tank 19, to feed the buffer tank 19 with the mixed powdery materials of the principal agent, the excipient, and the lubricant discharged from the horizontal mixer Z4.

More specifically, the first connecting pipe Z2 a includes a first branch pipe Z2 a 1 connected with the first measuring feeder Z1 a, a second branch pipe Z2 a 2 connected with the second measuring feeder Z1 b, and a main pipe Z2 a 3 connected with the first branch pipe Z2 a 1 and the second branch pipe Z2 a 2. The main pipe Z2 a 3 has a lower end connected with the vertical mixer Z3. The vertical mixer Z3 thus mixes the powdery materials measured and fed by the first measuring feeder Z1 a and the second measuring feeder Z1 b.

The second connecting pipe Z2 b, the third connecting pipe Z2 c, and the fourth connecting pipe Z2 d will be described later.

As shown exemplarily in FIGS. 5 to 8, the vertical mixer Z3 includes a lid Z36 having a feed port Z361 for a powdery material, a first case Z31 disposed below the lid Z36 and having a funnel shape, an agitation shaft Z33 disposed substantially in the center of the first case Z31 and configured to spin, an agitating rotor Z34 (i.e., a first mixing member) attached to the agitation shaft Z33, a motor Z37 configured to rotate (i.e., spin) the agitation shaft Z33, a powdery material passing member Z32 disposed below the first case Z31 and having a plurality of bores Z321, an auxiliary rotor Z35 (i.e., a first mixing member) configured to facilitate a powdery material to pass through the bores Z321 of the powdery material passing member Z32, and a second case Z38 covering the powdery material passing member Z32. The agitating rotor Z34 and the auxiliary rotor Z35 each function as the first mixing member. The configuration according to the exemplary embodiment includes both the agitating rotor Z34 and the auxiliary rotor Z35, while the exemplary invention is also applicable to another configuration including only one of the agitating rotor Z34 and the auxiliary rotor Z35.

The agitation shaft Z33 of the vertical mixer Z3 is not necessarily disposed vertically but can be slanted. The vertical mixer Z3 has only to be configured to agitate and mix powdery materials while the powdery materials fed from the feed port Z361 are flowing downward.

The powdery materials fed to the feed port Z361 of the vertical mixer Z3 are mixed by rotation of the agitating rotor Z34. The powdery materials can alternatively be mixed by rotation of the auxiliary rotor Z35.

The lid Z36 includes the feed port Z361 and a shaft port Z362 allowing the agitation shaft Z33 to pass therethrough, and is shaped to cover an upper opening of the first case Z31. The lid Z36 is attached to the first case Z31 so as to prevent a powdery material from spilling or scattering from the first case Z31. The feed port Z361 of the lid Z36 is connected with the first connecting pipe Z2 a. The powdery materials fed from the feed port Z361 into the first case Z31 are agitated and mixed by rotation of the agitating rotor Z34 and/or the auxiliary rotor Z35. The powdery material passing member Z32 disposed at a reservoir Z30 has the plurality of bores Z321 through which the mixed powdery materials pass.

Adjustment in amount of the powdery materials fed from the feed port Z361 or increase in a rotational speed of the auxiliary rotor Z35 can cause the powdery materials fed from the feed port Z361 to be larger in amount than the powdery materials passing through the bores Z321. A certain amount of the powdery materials will thus remain in the reservoir Z30. Specifically, at least part of the powdery materials measured and fed by the first measuring feeder Z1 a and the second measuring feeder Z1 b remain in the reservoir Z30 in the vertical mixer Z3 and is agitated by the auxiliary rotor Z35, to achieve improvement in mixing degree of the powdery materials. There can be included a plurality of feed ports Z361.

The first case Z31 has the open top and the powdery material passing member Z32 is disposed below the first case Z31. The first case Z31 according to the exemplary embodiment has the substantially funnel shape, while the first case Z31 is not limited to this shape but can have any shape if it is configured to feed the powdery material passing member Z32 with a powdery material.

The agitation shaft Z33 is disposed in the center of the first case Z31 in a planar view and is driven to rotate (i.e., spin) by the motor Z37. The agitating rotor Z34 is attached to each of the top and the center in the axial direction of the agitation shaft Z33, and the auxiliary rotor Z35 is attached to the lower end in the axial direction of the agitation shaft Z33. Rotation of the agitation shaft Z33 causes rotation of the agitating rotors Z34 and the auxiliary rotor Z35.

The agitating rotors Z34 (i.e., the first mixing members) agitate and mix the powdery materials fed from the feed port Z361 into the first case Z31. The agitating rotors Z34 can have any shape. The agitating rotors Z34 shown exemplarily in FIGS. 5 and 6 have a rectangular distal end and are disposed at two positions on the agitation shaft Z33. The vertical mixer Z3 shown exemplarily in FIG. 8 is configured partially differently from the vertical mixer Z3 shown exemplarily in FIGS. 5 and 6. The vertical mixer Z3 shown exemplarily in FIG. 8 includes the agitating rotor Z34 disposed at a single position on the agitation shaft Z33 and shaped differently from the agitating rotors Z34 shown exemplarily in FIGS. 5 and 6. The agitating rotors Z34 are not limited in terms of their shapes or positions to those shown exemplarily in FIGS. 5, 6, and 8.

As shown exemplarily in FIG. 7, the powdery material passing member Z32 at the reservoir Z30 is disposed below the first case Z31 and includes the plurality of bores Z321. The powdery material passing member Z32 is covered with the second case Z38. A powdery material passing through the bores Z321 of the powdery material passing member Z32 is discharged from a discharge port Z381 disposed at the bottom of the second case Z38. The number and the diameter of the bores Z321 are set appropriately. Such a configuration allows powdery materials to remain at the powdery material passing member Z32 and achieves improvement in mixing degree of the powdery materials. A powdery material passing through the bores Z321 of the powdery material passing member Z32 in a first vertical mixer Z3 a is fed to the horizontal mixer Z4 by way of the second connecting pipe Z2 b.

The auxiliary rotor Z35 agitates a powdery material in the reservoir Z30. The auxiliary rotor Z35 is disposed in the center of the reservoir Z30 in a planar view and is attached to the lower end of the agitation shaft Z33. The auxiliary rotor Z35 according to the exemplary embodiment is shaped to follow the inner shape of the powdery material passing member Z32 and facilitates a powdery material to pass through the bores Z321. The auxiliary rotor Z35 is also configured as a type of an agitating rotor.

The vertical mixer Z3 according to the exemplary embodiment includes the agitating rotor Z34. The vertical mixer Z3 can alternatively be configured by the second case Z38, the powdery material passing member Z32, and the auxiliary rotor Z35. The second case Z38 covers the powdery material passing member Z32, has a substantially funnel shape, and has the discharge port Z381 at the bottom. The second case Z38 guides a powdery material passing through the bores Z321 of the powdery material passing member Z32 to the discharge port Z381.

The second connecting pipe Z2 b connects the vertical mixer Z3 and the horizontal mixer Z4 to be described later. The second connecting pipe Z2 b is connected to the bottom of the vertical mixer Z3 and the top of the horizontal mixer Z4, to feed the horizontal mixer Z4 with the powdery materials passing through the discharge port Z381 of the vertical mixer Z3.

As shown exemplarily in FIG. 5, the horizontal mixer Z4 functioning as the second mixer includes a cylindrical case Z41, an agitation shaft Z42 disposed substantially in the center of the case Z41 and configured to spin, a motor Z43 configured to rotate (i.e., spin) the agitation shaft Z42, and an agitating rotor Z44 attached to the agitation shaft Z42 and configured to rotate to move a powdery material substantially horizontally. The horizontal mixer Z4 mixes the fed powdery materials, namely, the principal agent and the excipient or the like with the lubricant. The case Z41 according to the exemplary embodiment does not rotate (i.e., spin), but can alternatively be configured to rotate. This may achieve further improvement in mixing degree of the powdery materials.

The case Z41 has a top including a plurality of feed ports that allows powdery materials to be fed into the case Z41, and a discharge port Z413 that allows mixed powdery materials to be discharged from the case Z41. The configuration according to the exemplary embodiment includes two feed ports (e.g., first and second feed ports Z411 and Z412), and the second connecting pipe Z2 b is connected to the first feed port Z411 of the case Z41 of the horizontal mixer Z4. The first feed port Z411 feeds the case Z41 with the mixed powdery materials of the principal agent and the excipient or the like. The agitating rotor Z44 rotates to move the mixed powdery materials fed into the case Z41 toward the discharge port Z413 of the case Z41. The second feed port Z412 feeds the lubricant from the third connecting pipe Z2 c. The agitation shaft Z42 and the agitating rotor Z44 rotate to move the lubricant fed into the case Z41 toward the discharge port Z413 of the case Z41. Any of the feed ports not in use may be closed by a lid.

The discharge port Z413 is disposed at the bottom of the case Z41. The discharge port Z413 is connected with the fourth connecting pipe Z2 d to be described later. The agitating rotor Z44 rotates to discharge the mixed powdery materials from the case Z41 through the discharge port Z413 to the fourth connecting pipe Z2 d.

The agitation shaft Z42 extends in a longitudinal direction of the case Z41 and is disposed substantially in the center in a sectional view. The agitation shaft Z42 is driven to rotate (i.e., spin) by the motor Z43. As shown exemplarily in FIG. 9, the agitating rotor Z44 is attached to the agitation shaft Z42. Rotation of the agitation shaft Z42 causes rotation of the agitating rotor Z44 to simultaneously mix and move the powdery materials toward the discharge port Z413.

The agitating rotor Z44 is configured to agitate and mix the powdery materials fed into the case Z41 through the feed ports (e.g., Z411 and Z412). The agitating rotor Z44 can have any shape, but is preferably configured to simultaneously mix and move the powdery materials toward the discharge port Z413. As shown exemplarily in FIG. 9, the agitating rotor Z44 according to the exemplary embodiment is shaped to have both expanded ends, and is attached to the agitation shaft Z42 at a freely adjustable angle.

The third measuring feeder Z1 c is configured to measure and feed a lubricant to the horizontal mixer Z4. The third connecting pipe Z2 c is connected to the bottom of the third measuring feeder Z1 c. The lubricant in the third measuring feeder Z1 c is fed to the horizontal mixer Z4 through the third connecting pipe Z2 c. The lubricant can alternatively be fed to the horizontal mixer Z4 by a μR feeder (e.g., manufactured by Nisshin Engineering Inc.). The lubricant can still alternatively be fed to the horizontal mixer Z4 by an atomizer (e.g., spray device).

The third connecting pipe Z2 c includes a branch pipe Z2 c 1 and a main pipe Z2 c 2. The branch pipe Z2 c 1 has a first end connected to the bottom of the third measuring feeder Z1 c, and a second end connected to the main pipe Z2 c 2. The lower end of the main pipe Z2 c 2 is connected to the second feed port Z412 of the horizontal mixer Z4.

The fourth connecting pipe Z2 d has an upper end connected with the discharge port Z413 of the horizontal mixer Z4 and a lower end connected with the feed port Z361 of the buffer tank 19. The mixed powdery materials are fed through the discharge port Z413 of the horizontal mixer Z4 and the fourth connecting pipe Z2 d to the buffer tank 19.

The buffer tank 19 has a bottom connected to the compression-molding machine. The mixed powdery materials passing through the buffer tank 19 are delivered toward the feeder X in the molding machine by way of the powdery material mixing degree measurement device M and are eventually compression molded in the die bores 4.

The powdery-material feeding device Z according to the exemplary embodiment checks whether or not the mixing degree of the mixed powdery materials is within an appropriate range and whether or not the mixed powdery materials mixedly contain a biologically-originated foreign matter, like a human hair or a bug, and then feeds the powdery materials to the feeder X of the molding machine.

Examples of a method of measuring a mixing degree of mixed powdery materials include Raman spectroscopy, infrared spectroscopy, X-ray diffraction, X-ray transmission measurement, and high performance liquid chromatography (HPLC). Any one of these methods is applicable if the mixing degree of the mixed powdery materials is promptly measured. The same applies to a method of sensing foreign matter mixedly contained in a powdery material. Any method is applicable if such foreign matter is promptly detected. There is also an adoptable manner of irradiating, with near infrared light or the like, a powdery material passing a predetermined detection position on a powdery material flow passage, causing the near infrared light or the like having transmitted through the powdery material to be incident on a camera sensor to obtain an image of the transmitted light, and analyzing the obtained image to detect foreign matter like human hair or a bug.

There are provided detectors S1 to S5 configured to detect the mixing degree of the mixed powdery materials and to detect a foreign matter. These detectors S1 to S5 are dependent, in terms of their specific aspect, on a detection method thereof. The exemplary embodiment assumes adoption of a near infrared reflectance (NIR), or a near infrared absorption spectrum method. Specifically, in order to evaluate an amount or a percentage (i.e., ratio) of the principal agent in the mixed powdery materials (i.e., uniformity of the mixed powdery materials) (whether or not the mixed powdery materials are segregated), the mixed powdery materials moving from the powdery-material feeding device Z toward the feeder X of the molding machine are irradiated with near infrared light to measure light absorption (e.g., by detecting and dispersing transmitted light or reflected light) for qualitative and quantitative analyses of a concentration and the like of the principal agent based on a spectrum thereof. These analyses are repeatedly conducted at predetermined cycles. A measured wavelength falls in a wavelength range including a unique absorption peak of the principal agent and no peak of the excipient or the lubricant. The near infrared reflectance also enables measurement of particle diameters of the mixed powdery materials to sense the foreign matter mixedly contained in the powdery materials. When the near infrared reflectance method is adopted, process analytical technology (PAT) sensors functioning as the detectors S1 to S5 are configured by probes each including a near infrared sensor.

The mixed powdery materials delivered toward the feeder X of the molding machine by way of the buffer tank 19 of the powdery-material feeding device Z have the mixing degree promptly measured by the powdery material mixing degree measurement device M or the sensors S1 to S5 disposed on an upstream or a downstream of the powdery material mixing degree measurement device M, and are also promptly checked whether or not the foreign matter is mixedly contained. The mixed powdery materials having a mixing degree out of a predetermined range or mixedly containing the foreign matter are inhibited from being fed to the feeder X. This case also involves issuance of an alarm sound, a suspension of the powdery-material feeding device Z and the molding machine, and the like.

As shown exemplarily in FIGS. 10 and 11, the configuration according to the exemplary embodiment includes a first sensor S1 configured to initially measure the mixing degree of the mixed powdery materials and/or check whether or not the mixed powdery materials contain a biologically-originated foreign matter before the mixed powdery materials are reserved in the buffer tank 19.

After the first sensor S1 measures the mixing degree of the powdery materials and/or checks whether or not the mixed powdery materials contain foreign matter, the mixed powdery materials are temporarily reserved in the buffer tank 19 as a reservoir. After a second sensor S2 measures the mixing degree of the powdery materials reserved in the buffer tank 19 and/or checks whether or not the powdery materials contain foreign matter again, the powdery materials are fed to the powdery material mixing degree measurement device M. The mixed powdery materials can optionally be further agitated and mixed in the buffer tank 19.

As shown exemplarily in FIGS. 12 and 13, the powdery material mixing degree measurement device M includes a case M1, a rotator M2 as a movable member in the case M1, a motor M3 as a driver for the rotator M2, second and third sensors S2 and S3 configured to measure a mixing degree of powdery materials and/or check whether or not foreign matter is contained, a powdery-material removal mechanism M4 configured to remove defective mixed powdery materials, the feeding unit M5 configured to introduce the mixed powdery materials from the buffer tank 19 into the case M1, and the discharger M6 configured to discharge the mixed powdery materials to the agitated feeder X functioning as a filling device of the compression-molding machine.

As shown exemplarily in FIG. 14, the case M1 has a bottom surface including an attachment bore M11 allowing the third sensor S3 to be mounted therein, a removal bore M12 (the powdery-material removal mechanism M4) for removal of a powdery material, and a discharge bore M13 (the discharger M6) for discharge of a powdery material to the powdery-material feed pipe 191. The case M1 has a top surface on which the feeding unit M5 configured to feed the case M1 with a powdery material is mounted. The mixed powdery materials enter the case M1 by way of the buffer tank 19 and the feeding unit M5. The feeding unit M5 is provided with the second sensor S2 configured to measure a mixing degree of the mixed powdery materials passing through the feeding unit M5 and to check whether or not foreign matter is mixedly contained.

The rotator M2 includes a plurality of movable portions M21. The feeding unit M5 feeds the movable portions M21 with the mixed powdery materials. The rotator M2 is driven to rotate by the motor M3 positioned above the rotator M2.

The third sensor S3 is attached to the attachment bore M11 of the case M1, and is configured to measure a mixing degree of a powdery material fed to the movable portions M21 and/or check whether or not the powdery material fed to the movable portions M21 mixedly contains the foreign matter.

The powdery-material removal mechanism M4 includes a case, a drive body M41, and a driver M42 configured to drive the drive body M41. The case of the powdery-material removal mechanism M4 is provided integrally with the case M1. The drive body M41 according to the exemplary embodiment has a circular disc shape, and includes a center projection M411 engaged with the driver M42, and a partial cutoff portion M412. The driver M42 has a distal end M421 configured to drive forward and backward along a Y axis indicated in FIG. 13, and an engagement bore M422 disposed at the distal end and engaged with the projection M411 of the drive body M41.

In a state where the distal end M421 of the driver M42 moves in a positive direction along the Y axis as indicated in FIG. 13, the cutoff portion M412 of the drive body M41 is located in the center of the removal bore M12 of the case M1. In another state where the distal end M421 moves in a negative direction along the Y axis, the cutoff portion M412 is spaced apart from the removal bore M12 of the case M1.

Specifically, in the case where the driver M42 drives to move the distal end M421 in the negative direction along the Y axis, the drive body M41 is driven clockwise together therewith and the cutoff portion M412 is not overlapped with the removal bore M12. A powdery material in the movable portions M21 of the rotator M2 is not removed in this case. In the other case where the driver M42 drives to move the distal end M421 in the positive direction along the Y axis, the drive body M41 is driven counterclockwise together therewith and the cutoff portion M412 is overlapped with the removal bore M12. The powdery material in the movable portions M21 of the rotator M2 is removed in this case.

The drive body M41 according to the exemplary embodiment is driven clockwise and counterclockwise to remove the powdery material in the movable portions M21 of the rotator M2. The drive body M41 can alternatively be configured to rotate only in one direction to remove the powdery material in the movable portions M21.

If any of the first to third sensors S1 to S3 measures a mixing degree of the powdery materials (i.e., an amount or a percentage (i.e., ratio) of the principal agent in the mixed powdery materials, being out of the predetermined range), or detects a biologically-originated foreign matter mixedly contained in the mixed powdery materials, then the powdery-material removal mechanism M4 removes the mixed powdery materials in the movable portions M21. The mixed powdery materials in the movable portions M21 can be removed in a case where all the first to third sensors S1 to S3 have measurement values of mixing degrees out of the predetermined range or all the sensors S1 to S3 sense foreign matter, or in another case where any of the sensors S1 to S3 has a measurement value out of the predetermined range or any of the sensors S1 to S3 senses foreign matter.

The powdery-material removal mechanism M4 is also configured to sample the mixed powdery materials.

The mixed powdery materials not removed by the powdery-material removal mechanism M4 pass through the discharge bore M13 to reach the powdery-material feed pipe 191. The mixed powdery materials move to the discharger M6 in this case.

A fourth sensor S4 is configured to measure a mixing degree of the mixed powdery materials moved to the powdery-material feed pipe 191 and/or check whether or not foreign matter is mixedly contained before the mixed powdery materials are guided into the agitated feeder X functioning as a filling device of the compression-molding machine. Furthermore, a fifth sensor S5 is configured to measure a mixing degree of the mixed powdery materials and/or check whether or not foreign matter is mixedly contained, also in the agitated feeder X of the compression-molding machine according to the exemplary embodiment.

If the fourth sensor S4 and/or the fifth sensor S5 disposed downstream of the powdery-material removal mechanism M4 measures a mixing degree of the powdery materials out of the predetermined range or the fourth sensor S4 and/or the fifth sensor S5 senses a biologically-originated foreign matter, then the mixed powdery materials in the feeder X are once filled in each of the die bores 4 of the table 31 of the molding machine and are compression molded by the upper and lower punches 5 and 6 into the shape of a molded product. The molded product is then removed by the molded-product removal mechanism W before reaching the molded-product collecting position 18. Specifically, in the compression-molding machine, the control valve 22 is opened when the die bore 4 filled with defective mixed powdery materials tableted into a molded product passes by the air spray nozzle 16 a, and the air spray nozzle 16 a sprays air to blow the molded product out of the table 31.

The molded-product removal mechanism W removes a molded-product compression molded in any of the die bores 4 also in a case where any of the load cells 121 detects that compression pressure applied to the powdery material compressed in the die bore 4 is out of a predetermined range.

Summarized again below is a flow of continuous production of compression molded products by the molding machine system according to the exemplary embodiment. Initially, the first measuring feeder Z1 a simultaneously measures and feeds the principal agent, and the second measuring feeder Z1 b simultaneously measures and feeds the excipient or the like. The vertical mixer Z3 functioning as the first mixer is subsequently fed with the powdery materials of the principal agent and the excipient or the like and mixes the powdery materials therein. In the vertical mixer Z3, the agitating rotor Z34 rotates about the agitation shaft Z33 disposed substantially vertically, to mix the powdery materials of the principal agent and the excipient or the like.

The horizontal mixer Z4 functioning as the second mixer is fed with the mixed powdery materials of the principal agent and the excipient or the like subjected to the mixing by the first mixer, and mixes the powdery materials again. In the horizontal mixer Z4, the agitating rotor Z44 rotates about the agitation shaft Z42 disposed substantially horizontally, to mix the powdery materials of the principal agent and the excipient or the like. Such a process achieves improvement in mixing degree of the at least two types of powdery materials (e.g., the principal agent and the excipient or the like), and causes less segregation of the principal agent. The powdery materials having been mixed by the horizontal mixer Z4 can optionally be fed to an additional vertical mixer to be mixed again. This will achieve further improvement in mixing degree of the powdery materials.

The powdery materials are preferred to be reserved at least partially during mixing by the first mixer. Specifically, the powdery materials pass through the plurality of bores Z321 of the powdery material passing member Z32. The reservoir Z30 reserves powdery materials by increase in an amount of the powdery materials to be fed to the first vertical mixer Z3 a to be more than the powdery materials passing through the bores Z321 or increase in a rotational speed of the auxiliary rotor Z35. The powdery materials then pass through the bores Z321 while being agitated and mixed by the auxiliary rotor Z35.

Furthermore, the third measuring feeder Z1 c simultaneously measures and feeds the lubricant. The lubricant is fed to the horizontal mixer Z4 in the exemplary embodiment, but can alternatively be fed to a second vertical mixer Z3 b, the feeder X, or the like, with no limitation in feeding destination of the lubricant to the horizontal mixer Z4. The lubricant can be fed by the μR feeder (e.g., manufactured by Nisshin Engineering Inc.) or by an atomizer (e.g., spray device).

The mixed powdery materials including the principal agent, the excipient or the like, and the lubricant are fed to the buffer tank 19 of the molding machine.

As shown exemplarily in FIG. 16, the controller C in the molding machine system according to the exemplary embodiment causes the sensors S1 to S3 to repeatedly measure mixing degrees of the mixed powdery materials before and after being fed to the buffer tank 19, and causes the sensors S1 to S3 to repeatedly check whether or not the mixed powdery materials mixedly contain a biologically-originated foreign matter. If the measured mixing degree of the mixed powdery materials is out of the predetermined range or if foreign matter is detected in the mixed powdery materials, then the controller C starts the driver M42 of the powdery-material removal mechanism M4 included in the powdery-material feeding device Z to remove the mixed powdery materials before being fed to the feeder X of the molding machine.

The mixed powdery materials fed to the feeder X are filled in the die bores 4 of the table 31 of the turret 3 in the molding machine. Prior to filling each of the die bores 4 with the powdery materials in the compression-molding machine, a lubricant (e.g., external lubricant) can optionally be sprayed to a lower end surface of the upper punch 5, an upper end surface of the lower punch 6, and an inner circumferential surface of the die bore 4.

The mixed powdery materials filled in each of the die bores 4 are compression molded by the upper and lower punches 5 and 6. The mixed powdery materials compression molded into a molded product are guided by the guide member 17 and are collected at the molded-product collecting position 18.

However, the controller C in the compression-molding machine system according to the exemplary embodiment causes the sensors S4 and S5 to repeatedly measure the mixing degree of the mixed powdery materials fed to the feeder X and filled in the die bores 4 by the powdery-material feeding device Z, and further causes the sensors S4 and S5 to repeatedly check whether or not the mixed powdery materials mixedly contain a biologically-originated foreign matter. If the measured mixing degree of the mixed powdery materials is out of the predetermined range or if foreign matter is detected in the mixed powdery materials, then the molded-product removal mechanism W included in the molding machine removes a defective molded-product compression molded in the die bore 4 filled with the mixed powdery materials. Specifically, the control valve 22 is opened when the die bore 4 filled with the defective molded product passes by the air spray nozzle 16 a, and the air spray nozzle 16 a sprays compressed air to blow the molded product out of the table 31.

The controller C further causes the load cells 121 to measure a compression pressure applied from the punches 5 and 6 to the powdery materials in each of the die bores 4 to obtain a molded product. In a case where compression pressure is out of a predetermined range, the controller C causes the molded-product removal mechanism W to remove a defective molded-product compression molded in the die bore 4 having compression pressure out of the predetermined range. In a case where a powdery material filled in the die bore 4 is more than an appropriate amount, compression pressure measured by the load cell 121 exceeds the predetermined range. In another case where the powdery material filled in the die bore 4 is less than the appropriate amount, compression pressure measured by the load cell 121 is less than the predetermined range. In either one of the cases, the molded-product compression molded in the die bore 4 has weight, density, and hardness different from desired values and is regarded as defective.

When the die bore 4 assumed to be filled with the mixed powdery materials having a mixing degree out of the predetermined range or mixedly containing foreign matter or the die bore 4 receiving compression pressure out of the predetermined range (i.e., the possibly defective molded product), passes by the air spray nozzle 16 a, is found by referring to an output signal from the rotary encoder 23.

When any of the sensors S1 to S5 detects the mixing degree of the mixed powdery materials out of the predetermined range or detects foreign matter mixedly contained in the mixed powdery materials, the controller C can stop the feeding of the powdery materials by the powdery-material feeding device Z or stop an operation of the molding machine.

Originally, the first measuring feeder Z1 a is configured to feedback control weight (i.e., a flow rate) of the fed principal agent per unit time, the second measuring feeder Z1 b is configured to feedback control weight of the fed excipient or the like per unit time, and the third measuring feeder Z1 c is configured to feedback control weight of the fed lubricant per unit time. Furthermore, these powdery materials are to be mixed at a desired mixture ratio. Even in this configuration, the amounts of the powdery materials discharged from the measuring feeders Z1 and fed to the mixers Z3 and Z4 can somehow deviate from initial target amounts. The powdery material fed from any of the measuring feeders Z1 to the mixer Z3 or Z4 is sometimes smaller than the target amount. In such a case, the amount of the principal agent in the mixed powdery materials has a ratio larger or smaller than the desired ratio. A molded product obtained by compression-molding such mixed powdery materials is defective, failing to exert an expected drug effect.

Even if the mixer Z3 or Z4 fails to adequately mix the powdery materials and the mixed powdery materials fed to the feeder X of the molding machine have segregation of the principal agent or the excipient, molded products will be defective with different contents.

In view of this, the controller C of the molding machine system according to the exemplary embodiment adjusts, in accordance with the mixing degree measurement value of the mixed powdery materials by any of the first to fifth sensors S1 to S5, the amounts of the powdery materials fed by the measuring feeders Z1 a to Z1 c, a rotational speed of the agitation shaft Z33, the agitating rotor Z34, and the auxiliary rotor Z35 of the vertical mixer Z3, and a rotational speed of the agitation shaft Z42 and the agitating rotor Z44 of the horizontal mixer Z4. Examples of the controller C include a microcomputer system including a processor, a memory, an auxiliary storage device, and an input/output interface, a programmable controller, a general-purpose personal computer, and a general-purpose work station.

In a case where the absolute value of a difference between a target value and the amount or the percentage of the principal agent in the mixed powdery materials repeatedly measured by any of the first to fifth sensors S1 to S5 is more than a predetermined threshold (i.e., the percentage of the principal agent is inappropriately small or large) continuously for at least a certain period, at least one of the first to third measuring feeders Z1 a to Z1 c is regarded as failing to feed an appropriate amount of the powdery material. In this case, the controller C temporarily interrupts weight feedback control by the measuring feeders Z1 themselves and adjusts a rotational speed of a drive motor of each of the measuring feeders Z1 such that the amount or the percentage of the principal agent in the mixed powdery materials measured by any of the first to fifth sensors S1 to S5 is approximate to the target value. In a case where the measured amount or the measured percentage of the principal agent in the mixed powdery materials is less than the target value, the first measuring feeder Z1 a increases the amount of the discharged principal agent, and/or the second measuring feeder Z1 b decreases the amount of the discharged excipient or the like and the third measuring feeder Z1 c decreases the amount of the discharged lubricant. In another case where the measured amount or the measured percentage of the principal agent in the mixed powdery materials is more than the target value, the first measuring feeder Z1 a decreases the amount of the discharged principal agent, and/or the second measuring feeder Z1 b increases the amount of the discharged excipient or the like and the third measuring feeder Z1 c increases the amount of the discharged lubricant.

Alternatively, if the absolute value of the difference between the target value and the amount or the percentage of the principal agent in the mixed powdery materials is more than the threshold continuously for at least the certain period, then the target value of the amount of the discharged powdery materials commanded by the controller C to the measuring feeders Z1 a to Z1 c can be changed to optimize the amount of the fed principal agent. In a case where the measured amount or the measured percentage of the principal agent in the mixed powdery materials is less than the target value, the first measuring feeder Z1 a has a higher target value of the amount of the discharged principal agent, and/or the second measuring feeder Z1 b has a lower target value of the amount of the discharged excipient or the like and the third measuring feeder Z1 c has a lower target value of the amount of the discharged lubricant.

In another case where the measured amount or the measured percentage of the principal agent in the mixed powdery materials is more than the target value, the first measuring feeder Z1 a has a lower target value of the amount of the discharged principal agent, and/or the second measuring feeder Z1 b has a higher target value of the amount of the discharged excipient or the like and the third measuring feeder Z1 c has a higher target value of the amount of the discharged lubricant.

In a case where the absolute value of the difference between the target value and the amount or the percentage of the principal agent in the mixed powdery materials repeatedly measured by any of the first to fifth sensors S1 to S5 is more than the threshold not continuously for at least the certain period but is more than the threshold instantaneously or only for a short period, (e.g., the principal agent, the excipient or the like, or the lubricant in) the mixed powdery materials moving toward the feeder X of the compression-molding machine is regarded as having segregation (i.e., locally having portions of high and low concentrations of the principal agent). In this case, the controller C changes (e.g., increases or decreases) a current rotational speed of each of the agitation shaft Z33 and the agitating rotors Z34 and Z35 of the vertical mixer Z3, and/or changes (e.g., increases or decreases) a current rotational speed of each of the agitation shaft Z42 and the agitating rotor Z44 of the horizontal mixer Z4, for further improvement in mixing degree of the powdery materials.

Also, in the case where the absolute value of the difference between the target value and the amount or the percentage of the principal agent in the mixed powdery materials is more than the threshold continuously for at least the certain period, the controller C can control to change a current rotational speed of the agitating rotors Z34 and Z35 of the vertical mixer Z3 and/or to change a current rotational speed of the agitating rotor Z44 of the horizontal mixer Z4.

As described above, increasing or decreasing each of the amounts of the powdery materials discharged from the measuring feeders Z1 a to Z1 c, changing a rotational speed of the agitation shaft Z33 of the vertical mixer Z3, or changing a rotational speed of the agitation shaft Z42 of the horizontal mixer Z4 can possibly cause change in flow rate per unit time of the mixed powdery materials fed to the powdery-material feed pipe 191 connected to the feeder X of the molding machine. When any of the sensors S1 to S3 detects a mixing degree of the mixed powdery materials is out of the predetermined range or detects a mixedly contained foreign matter, the powdery-material removal mechanism M4 removes the powdery materials, to possibly temporarily decrease the flow rate per unit time of the mixed powdery materials fed to the powdery-material feed pipe 191.

If the turret 3 and the punches 5 and 6 of the molding machine are kept rotating at a constant rotational speed despite variation in flow rate of the mixed powdery materials moving toward the powdery-material feed pipe 191, then the mixed powdery materials accumulated in the powdery-material feed pipe 191 have an upper surface L at a varied level because the molding machine uses a constant amount of the mixed powdery materials per unit time. The level of the upper surface L of a powdery material in the powdery-material feed pipe 191 is raised in a case where the powdery material fed to the powdery-material feed pipe 191 has a flow rate per unit time more than the amount of the powdery material used by the molding machine per unit time. The level of the upper surface L of the powdery material in the powdery-material feed pipe 191 is lowered in another case where the powdery material fed to the powdery-material feed pipe 191 has a flow rate per unit time less than the amount of the powdery material used by the molding machine per unit time.

Large variation in a level of the upper surface L of the powdery material in the powdery-material feed pipe 191 disposed above and directly connected to the feeder X may lead to an increase or a decrease from the appropriate amount of the powdery material filled into the die bores 4 from the feeder X and defectiveness of the product molded in the die bores 4.

In order to inhibit such a variation in an amount of the filled powdery material, the controller C according to the exemplary embodiment causes a sensor S6 to detect the level of the upper surface L of the mixed powdery materials in the powdery-material feed pipe 191 and adjusts a rotational speed of the motor 8, eventually the turret 3 and the punches 5 and 6 of the molding machine in accordance with the level of the upper surface.

As shown exemplarily in FIG. 19, the powdery-material feed pipe 191 has two capacitance level switches S61 and S62 each functioning as the sensor S6. The level switches S61 and S62 are configured to detect whether the level of the upper surface L of a powdery material accumulated in the powdery-material feed pipe 191 is higher or lower than the level switches S61 and S62, respectively. The controller C is configured to determine, with use of the level switches S61 and S62, whether the level of the upper surface L of the powdery material in the feed pipe 191 is above the upper level switch S61, is below the upper level switch S61 and above the lower level switch S62, or is below the lower level switch S62. When the level of the upper surface L of the powdery material in the feed pipe 191 is below the upper level switch S61 and above the lower level switch S62, the upper surface level of the powdery material is regarded as being within a desired target range.

In a case where the upper surface level of the powdery material in the powdery-material feed pipe 191 is not lower than the upper limit of the target range (i.e., when the upper surface level is not lower than the upper level switch S61), the controller C according to the exemplary embodiment increases a rotational speed of the turret 3 and the punches 5 and 6 of the molding machine in comparison to a case where the upper surface level is within the target range. This leads to an increase in an amount of the powdery material used by the molding machine per unit time and decrease in upper surface level of the powdery material in the powdery-material feed pipe 191 to be within the target range.

In another case where the upper surface level of the powdery material in the powdery-material feed pipe 191 is not higher than the lower limit of the target range (i.e., when the upper surface level is not higher than the lower level switch S62), the controller C decreases a rotational speed of the turret 3 and the punches 5 and 6 of the molding machine in comparison to the case where the upper surface level is within the target range. This leads to a decrease in an amount of the powdery material used by the molding machine per unit time and an increase in the upper surface level of the powdery material in the powdery-material feed pipe 191 to be within the target range.

When the rotational speed of the turret 3 and the punches 5 and 6 of the molding machine is controlled, a period of an increase in a rotational speed while the upper surface level of the powdery material in the powdery-material feed pipe 191 decreases from the upper limit toward the lower limit of the target range, and a period of a decrease in a rotational speed while the upper surface level of the powdery material in the feed pipe 191 increases from the lower limit toward the upper limit of the target range, can repeat alternately.

As indicated in FIG. 20, the controller C according to the exemplary embodiment controls, under such a condition, a rotational speed of the turret 3 and the punches 5 and 6 in a first period of an increase in a speed and a subsequent second period of an increase in the speed such that the second period is longer than the first period. For example, the rotational speed of the turret 3 and the punches 5 and 6 in the subsequent second period of an increase in the speed is made lower than the rotational speed of the turret 3 and the punches 5 and 6 in the first period of increase in speed.

The controller C also controls the rotational speed of the turret 3 and the punches 5 and 6 in a first period of decrease in speed and a subsequent second period of a decrease in the speed such that the second period is longer than the first period. For example, the rotational speed of the turret 3 and the punches 5 and 6 in the subsequent second period of an increase in the speed is made higher than the rotational speed of the turret 3 and the punches 5 and 6 in the first period of increase in speed. Such control eventually allows the upper surface level of the powdery material in the powdery-material feed pipe 191 to stably be kept without reaching the upper limit or the lower limit of the target range.

As already described, the powdery-material removal mechanism M4 of the powdery-material feeding device Z configured to deliver a powdery material toward the powdery-material feed pipe 191 occasionally removes the defective powdery material without feeding to the powdery-material feed pipe 191. Removal of such a powdery material by the powdery-material removal mechanism M4 leads to a decrease in an amount of the powdery material delivered toward the powdery-material feed pipe 191 per unit time, so that the upper surface level of the powdery material in the powdery-material feed pipe 191 may be decreased.

In a case where the powdery-material removal mechanism M4 removes the powdery material even though the upper surface level of the powdery material is below the upper level switch S61 and above the lower level switch S62, the controller C according to the exemplary embodiment conducts a feed-forward control of decreasing a rotational speed of the turret 3 and the punches 5 and 6 of the molding machine in comparison to the contrast case. Specifically, when the controller C receives a signal indicating that the driver M42 in the powdery-material removal mechanism M4 operates and the powdery material captured by the movable portions M21 of the rotator M2 is dropped into the removal bore M12, the controller C decreases a current rotational speed of the turret 3 and the punches 5 and 6. Assume that the rotational speed of the turret 3 and the punches 5 and 6 has a value obtained by multiplying the rotational speed immediately before the decrease in speed and a coefficient (larger than zero and) smaller than one.

When the controller C controls to decrease the rotational speed of the turret 3 and the punches 5 and 6 of the molding machine in response to removal of the powdery material by the powdery-material removal mechanism M4, the rotational speed is decreased preferably at a rate according to the rotational speed immediately before the decrease in speed.

In a case where the turret 3 and the punches 5 and 6 immediately before the decrease in speed have a relatively high rotational speed, the powdery-material feeding device Z feeds the powdery-material feed pipe 191 and eventually the feeder X with the powdery material originally having a large flow rate per unit time. Meanwhile, the powdery-material removal mechanism M4 removes, at one time, the powdery material having a fundamentally constant amount equal to that of the powdery material captured by one of the movable portions M21 of the rotator M2. Accordingly, in a case where the powdery material is removed while the turret 3 and the punches 5 and 6 have a relatively high rotational speed, the powdery-material feeding device Z feeds the powdery-material feed pipe 191 with the powdery material having a small decrease rate per unit time and such removal has a relatively small influence. The rotational speed of the turret 3 and the punches 5 and 6 of the molding machine can thus have a small decrease rate upon removal of the powdery material, so that the coefficient multiplied by the rotational speed immediately before the decrease in the speed is set to have a larger value.

In another case where the turret 3 and the punches 5 and 6 have a relatively low rotational speed immediately before the decrease in speed, the powdery-material feeding device Z feeds the powdery-material feed pipe 191 with the powdery material originally having a small flow rate per unit time. Meanwhile, the powdery-material removal mechanism M4 removes, at one time, the powdery material having a fundamentally constant amount. If the powdery material is removed while the turret 3 and the punches 5 and 6 have a relatively low rotational speed, then the powdery-material feeding device Z feeds the powdery-material feed pipe 191 with the powdery material having a large decrease rate per unit time and such removal has a relatively large influence. The rotational speed of the turret 3 and the punches 5 and 6 of the molding machine thus needs to have a large decrease rate upon removal of the powdery material, so that the coefficient multiplied by the rotational speed immediately before the decrease in speed is set to have a smaller value.

The exemplary embodiment provides the powdery-material feeding device Z configured to feed a powdery material to the compression-molding machine configured to obtain a molded product by filling the die bore 4 with the powdery material and to compress the powdery material with the punches 5 and 6. The powdery-material feeding device Z includes the detector S1, S2, or S3 configured to detect a biologically-originated foreign matter mixedly contained in the powdery material to be fed to the compression-molding machine. The controller C is configured to control to remove the powdery material mixedly containing the biologically-originated foreign matter detected by the detector S1, S2, or S3 to avoid feeding of the powdery material mixedly containing the foreign matter to the compression-molding machine, or to control to stop the feeding of the powdery material to the compression-molding machine. The exemplary embodiment prevents feeding, to the compression-molding machine, of a powdery material mixedly containing a biologically-originated foreign matter, to effectively avoid production of a molded product containing the foreign matter.

The powdery-material feeding device Z according to the exemplary embodiment is configured to feed the molding machine with mixed powdery materials containing at least two types of powdery materials, includes the detectors S1 to S3 configured to measure a mixing degree of the mixed powdery materials to be fed to the compression-molding machine. When the mixing degree of the mixed powdery materials detected by any of the detectors S1 to S3 is out of the predetermined range, the controller C controls to remove the mixed powdery materials so as not to be fed to the molding machine or controls to stop feeding of the mixed powdery materials to the molding machine. The exemplary embodiment may prevent feeding, to the molding machine, of mixed powdery materials having a mixing degree out of a normal range, to effectively avoid production of a defective molded product not satisfying desired quality.

The feeder X as a filling device in the molding machine causes a powdery material to fall into the die bores 4 of the table 31 by weight of the powdery material. Excessiveness or shortage from the appropriate amount of the powdery material filled in the die bores 4 leads to finished products having weight, density, and hardness different from the desired values. The powdery material filled in the die bores 4 needs to have a variation in an amount as small as possible. Constantly keeping the upper surface level of the powdery material in the feed pipe 191 (i.e., constantly keeping pressure of the powdery material in the feeder X), is effective for constantly filling the die bores 4 with a constant amount of the powdery material from the feeder X. According to the exemplary embodiment, the powdery-material removal mechanism M4 in the powdery-material feeding device Z occasionally removes the powdery material before being fed to the feeder X and the powdery material fed from the powdery-material feeding device Z toward the feeder X has a flow rate not necessarily constant per unit time. Correspondingly to the increased or decreased flow rate, the controller C adjusts a rotational speed of the turret 3 and the punches 5 and 6 of the rotary compression-molding machine to keep the upper surface level of the powdery material in the feed pipe 191 within the constant target range. This achieves a precisely stabilized appropriate amount of the powdery material filled in the die bores 4, to keep high quality of the molded products obtained from the powdery material in the die bores 4.

The invention is not limited to the exemplary embodiment detailed above. For example, the above exemplary embodiment applies the detectors S1 to S5 configured to check whether or not the mixed powdery materials to be fed from the powdery-material feeding device Z to the feeder X of the compression-molding machine mixedly contain a biologically-originated foreign matter and the detectors S1 to S5 configured to measure a mixing degree of the mixed powdery materials. The exemplary invention is also applicable to a case where the detectors for the former purpose and the detectors for the latter purpose are independent from each other or are disposed at positions different from each other.

Furthermore, a type of foreign matter possibly mixed in a powdery material can vary a calibration curve for detection of the foreign matter. In such a case, a detector (e.g., a near infrared reflectance probe) configured to detect a certain type of foreign matter (e.g., a human hair) can be disposed separately from a detector configured to detect a different type of a foreign matter (e.g., a bug).

The level of the upper surface L of the powdery material in the feed pipe 191 is detected by the two level switches S61 and S62 in the above exemplary embodiment. The sensor S6 configured to detect a level of the upper surface L of the powdery material is, however, not limited to these level switches S61 and S62. Examples of the sensor S6 also include a contact level gauge configured to directly contact the powdery material accumulated in the feed pipe 191 and measure the level of the upper surface L, and a contactless level gauge configured to emit an ultrasonic wave or an electromagnetic wave toward the upper surface L of the powdery material and receive a reflected wave thereof to measure the level of the upper surface L of the powdery material. The level of the upper surface L of the powdery material can alternatively be obtained by photographing the interior of the feed pipe 191 with a camera sensor and analyzing a captured image with the controller C.

According to the above exemplary embodiment, a rotational speed of the turret 3 and the punches 5 and 6 of the molding machine is adjusted such that the level of the upper surface L of the powdery material in the feed pipe 191 directly connected to the filling device X is kept within the constant target range. Alternatively, the filling device X can have a level switch or a level gauge configured to obtain an upper surface level of a powdery material in the filling device X (particularly in a case where the filling device X is configured by a gravity feeder) in order for adjustment of a rotational speed of the turret 3 and the punches 5 and 6 of the molding machine such that the upper surface level of the powdery material in the filling device X is kept within the constant target range.

In this case, the rotational speed of the turret 3 and the punches 5 and 6 is increased if the upper surface level of the powdery material in the filling device X is not lower than the upper limit of the target range, whereas the rotational speed of the turret 3 and the punches 5 and 6 is decreased if the upper surface level of the powdery material in the filling device X is not higher than the lower limit of the target range.

In addition, when there are the period of an increase in a rotational speed of the turret 3 and the punches 5 and 6 to allow the upper surface level of the powdery material in the filling device X to be lowered from at or above the upper limit of the target range toward the lower limit of the target range and the period of a decrease in the rotational speed of the turret 3 and the punches 5 and 6 to allow the upper surface level of the powdery material in the filling device X to be raised from at or below the lower limit of the target range toward the upper limit of the target range, the controller C preferably controls the rotational speed of the turret 3 and the punches 5 and 6 such that the subsequent second period of increase in speed is longer than the first period of increase in speed, and preferably controls the rotational speed of the turret 3 and the punches 5 and 6 such that the subsequent second period of decrease in speed is longer than the first period of decrease in speed.

The controller C further preferably decreases the rotational speed of the turret 3 and the punches 5 and 6 in a case where the powdery-material removal mechanism M4 included in the device Z configured to deliver a powdery material toward the feed pipe 191 and the filling device X, and removes the powdery material without feed of the predetermined amount of the powdery material to the feed pipe 191.

The controller C can alternatively conduct a feedback control of precisely adjusting the rotational speed of the turret 3 and the punches 5 and 6 of the molding machine in accordance with a degree of a difference between the level of the upper surface L of the powdery material detected by the sensor S6 and a target value (which can be a median value, the upper limit, or the lower limit of the target range) so as to keep the level of the upper surface L of the powdery material accumulated in the feed pipe 191 or in the filling device X within the target range. In a case where the upper surface level of the powdery material is higher than the target value, the rotational speed of the turret 3 and the punches 5 and 6 of the molding machine is decreased as the absolute value of the difference between the upper surface level and the target value is larger. In another case where the upper surface level of the powdery material is lower than the target value, the rotational speed of the turret 3 and the punches 5 and 6 of the molding machine is increased as the absolute value of the difference between the upper surface level and the target value is larger. The controller C embodies a controller in a control system, which can be designed in any appropriate manner. Examples of the manner of designing the controller in the control system include various manners such as a Proportional Integral Derivative (PID) control, a model-based predictive control, and a learning control.

Alternatively, in order to keep the level of the upper surface L of the powdery material accumulated in the feed pipe 191 or in the filling device X within the target range, the controller C can measure the flow rate of the powdery material fed to the feed pipe 191 with a flowmeter and control to increase the rotational speed of the turret 3 and the punches 5 and 6 if the flow rate is large.

Further, in order to keep the level of the upper surface L of the powdery material accumulated in the feed pipe 191 or in the filling device X within the target range, the controller C can measure a pressure (i.e., from the accumulated powdery material) in the feed pipe 191 or in the filling device X with a pressure gauge and control to increase the rotational speed of the turret 3 and the punches 5 and 6 if the internal pressure is large.

Moreover, specific configurations of the respective portions can be modified without departing from the scope of the exemplary invention.

The descriptions of the various exemplary embodiments of the present invention have been presented for purposes of illustration, but are not intended to be exhaustive or limited to the embodiments disclosed. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The terminology used herein was chosen to best explain the principles of the embodiments, the practical application or technical improvement over technologies found in the marketplace, or to enable others of ordinary skill in the art to understand the embodiments disclosed herein.

Further, Applicant's intent is to encompass the equivalents of all claim elements, and no amendment to any claim of the present application should be construed as a disclaimer of any interest in or right to an equivalent of any element or feature of the amended claim. 

What is claimed is:
 1. A powdery-material feeding device configured to feed a powdery material to a compression-molding machine configured to obtain a molded product by filling a die bore with the powdery material and to compress the powdery material with punches, the powdery-material feeding device comprising: a detector configured to detect a biologically-originated foreign matter mixedly contained in the powdery material to be fed to the compression-molding machine; and a controller configured to control to remove the powdery material mixedly containing the biologically-originated foreign matter detected by the detector to avoid feeding of the powdery material mixedly containing the biologically-originated foreign matter to the compression-molding machine, or to control to stop the feeding of the powdery material to the compression-molding machine, wherein the controller is programmed such that, after the detector detects the biologically-originated foreign matter, the punches move with a speed that is different from the speed of the punches when the punches move before the detector detects the biologically-originated foreign matter, and wherein the different speed maintains an upper surface level of the powdery material in a feed pipe, located above the die bore, within a constant target range.
 2. The powdery-material feeding device according to claim 1, the powdery-material feeding device being further configured to feed the compression-molding machine with mixed powdery materials containing at least two types of powdery materials, the powdery-material feeding device further comprising: another detector configured to measure a mixing degree of the mixed powdery materials to be fed to the compression-molding machine, wherein, when the mixing degree of the mixed powdery materials detected by said another detector is out of a predetermined range, the controller controls to remove the mixed powdery materials to avoid the feeding to the compression-molding machine, or controls to stop the feeding of the mixed powdery materials to the compression-molding machine.
 3. The powdery-material feeding device according to claim 1, wherein the compression-molding machine comprises a rotary compression-molding machine and is further configured to rotate a turret including a table including the die bore, and punch retaining portions vertically slidably retaining punches disposed above and below the die bore, along with the punches, and to fill the die bore with the powdery material from a filling device disposed above the table, to compress the powdery material filled in the die bore with the punches, and to obtain the molded product, and wherein the controller controls to adjust a rotational speed of the turret and the punches of the rotary compression-molding machine to allow the powdery material in the feed pipe, directly connected to the filling device and configured to feed the powdery material toward the filling device or in the filling device, to have the upper surface level kept within the constant target range.
 4. The powdery-material feeding device according to claim 2, wherein the compression-molding machine comprises a rotary compression-molding machine and is further configured to rotate a turret including a table including the die bore, and punch retaining portions vertically slidably retaining punches disposed above and below the die bore, along with the punches, and to fill the die bore with the powdery material from a filling device disposed above the table, to compress the powdery material filled in the die bore with the punches, and to obtain the molded product, and wherein the controller controls to adjust a rotational speed of the turret and the punches of the rotary compression-molding machine to allow the powdery material in the feed pipe, directly connected to the filling device and configured to feed the powdery material toward the filling device or in the filling device, to have the upper surface level kept within the constant target range.
 5. A method of feeding a powdery material to a compression-molding machine configured to obtain a molded product by filling a die bore with the powdery material and to compress the powdery material with punches, the powdery-material feeding method comprising: detecting a biologically-originated foreign matter mixedly contained in the powdery material to be fed to the compression-molding machine; and controlling to remove the powdery material mixedly containing the biologically-originated foreign matter detected during the detecting to avoid the feeding of the powdery material mixedly containing the biologically-originated foreign matter to the compression-molding machine or controlling to stop the feeding of the powdery material to the compression-molding machine, wherein, after the detecting the biologically-originated foreign matter, the punches move with a speed that is different from the speed of the punches when the punches move before the detector detects the biologically-originated foreign matter, and wherein the different speed maintains an upper surface level of the powdery material in a feed pipe, located above the die bore, within a constant target range.
 6. The powdery-material feeding method according to claim 5, the method being applied to feed the compression-molding machine with mixed powdery materials containing at least two types of powdery materials, the method further comprising: detecting, by measuring, a mixing degree of the mixed powdery materials to be fed to the compression-molding machine; and controlling to remove the mixed powdery materials to avoid the feeding to the compression-molding machine or controlling to stop the feeding of the mixed powdery materials to the compression-molding machine when the mixing degree of the mixed powdery materials measured during the detecting is out of a predetermined range.
 7. The powdery-material feeding method according to claim 5, wherein the compression-molding machine comprises a rotary compression-molding machine and is further configured to rotate a turret including a table including a die bore, and punch retaining portions vertically slidably retaining punches disposed above and below the die bore, along with the punches, and to fill the die bore with a powdery material from a filling device disposed just above the table, to compress the powdery material filled in the die bore with the punches, and to obtain the molded product, and wherein the powdery-material feeding method further comprises controlling to adjust a rotational speed of the turret and the punches of the rotary compression-molding machine to allow the powdery material in the feed pipe, directly connected to the filling device and configured to feed the powdery material toward the filling device, or in the filling device to have the upper surface level kept within the constant target range.
 8. The powdery-material feeding method according to claim 6, wherein the compression-molding machine comprises a rotary compression-molding machine and is further configured to rotate a turret including a table including a die bore, and punch retaining portions vertically slidably retaining punches disposed above and below the die bore, along with the punches, and to fill the die bore with the powdery material from a filling device disposed just above the table, to compress the powdery material filled in the die bore with the punches, and to obtain the molded product, and wherein the powdery-material feeding method further comprises controlling to adjust a rotational speed of the turret and the punches of the rotary compression-molding machine to allow the powdery material in the feed pipe, directly connected to the filling device and configured to feed the powdery material toward the filling device, or in the filling device to have the upper surface level kept within the constant target range.
 9. A powdery-material feeding system, comprising: a compression-molding machine configured to obtain a molded product by filling a die bore with a powdery material and to compress the powdery material with punches; and a powdery-material feeding device configured to feed the powdery material to the compression-molding machine, the powdery-material feeding device comprising: a detector configured to detect a biologically-originated foreign matter mixedly contained in the powdery material to be fed to the compression-molding machine; and a controller configured to control to remove the powdery material mixedly containing the biologically-originated foreign matter detected by the detector to avoid feeding of the powdery material mixedly containing the biologically-originated foreign matter to the compression-molding machine, or to control to stop the feeding of the powdery material to the compression-molding machine, wherein the controller is programmed such that, after the detector detects the biologically-originated foreign matter, the punches move with a speed that is different from the speed of the punches when the punches move before the detector detects the biologically-originated foreign matter, and wherein the different speed maintains an upper surface level of the powdery material in a feed pipe, located above the die bore, within a constant target range.
 10. The powdery-material feeding system according to claim 9, the powdery-material feeding device being further configured to feed the compression-molding machine with mixed powdery materials containing at least two types of powdery materials.
 11. The powdery-material feeding system according to claim 10, the powdery-material feeding device further comprising: another detector configured to measure a mixing degree of the mixed powdery materials to be fed to the compression-molding machine.
 12. The powdery-material feeding system according to claim 11, wherein, when the mixing degree of the mixed powdery materials detected by said another detector is out of a predetermined range, the controller controls to remove the mixed powdery materials to avoid the feeding to the compression-molding machine.
 13. The powdery-material feeding system according to claim 11, wherein, when the mixing degree of the mixed powdery materials detected by said another detector is out of a predetermined range, the controller controls to stop the feeding of the mixed powdery materials to the compression-molding machine.
 14. The powdery-material feeding system according to claim 9, wherein the compression-molding machine comprises a rotary compression-molding machine and is further configured to rotate a turret including a table including the die bore, and punch retaining portions vertically slidably retaining punches disposed above and below the die bore, along with the punches, and to fill the die bore with the powdery material from a filling device disposed above the table, to compress the powdery material filled in the die bore with the punches, and to obtain the molded product.
 15. The powdery-material feeding system according to claim 14, wherein the controller controls to adjust a rotational speed of the turret and the punches of the rotary compression-molding machine to allow the powdery material in the feed pipe, directly connected to the filling device and configured to feed the powdery material toward the filling device or in the filling device, to have the upper surface level kept within the constant target range.
 16. The powdery-material feeding system according to claim 15, wherein the controller is further programmed to control the rotational speed of the turret and the speed of the punches such that a first period of an increase in the rotational speed is shorter than a subsequent second period of the increase in the rotational speed.
 17. The powdery-material feeding system according to claim 16, wherein the controller is further programmed to control the rotational speed of the turret and the punches such that a first period of a decrease in the rotational speed is shorter than a subsequent second period of the decrease in the rotational speed.
 18. The powdery-material feeding system according to claim 9, wherein the speed of the punches, after the detector detects the biologically-originated foreign matter, is less than the speed of the punches before the detector detects the biologically-originated foreign matter.
 19. The powdery-material feeding device according to claim 1, wherein, the speed of the punches, after the detector detects the biologically-originated foreign matter, is less than the speed of the punches before the detector detects the biologically-originated foreign matter.
 20. The powdery-material feeding device according to claim 3, wherein the controller is further programmed to control the rotational speed of the turret and the speed of the punches such that a first period of an increase in the rotational speed is shorter than a subsequent second period of the increase in the rotational speed, and wherein the controller is further programmed to control the rotational speed of the turret and the punches such that a first period of a decrease in the rotational speed is shorter than a subsequent second period of the decrease in the rotational speed. 